2. Protéines recombinantes
  3. Cytokines and Growth Factors
  4. EGF Superfamily
  5. Neuregulins
  6. Neuregulin-1 (NRG1)
  7. Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc)

Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc)

Cat. No.: HY-P74710
Instruction de manipulation Technical Support

Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293, with N-mFc labeled tag.

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Description

Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc) is the recombinant canine-derived Neuregulin-1/NRG1 protein, expressed by HEK293, with N-mFc labeled tag.
Background

NRG1 Protein binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). It induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neuronssup>[1][2].
Species

Canine
Source

HEK293
Tag

N-mFc
Accession

A0A3Q7RTD6/XP_858147 (S176-K240)
Gene ID

482861  [NCBI]
Molecular Construction
N-term
mFc
NRG1 (S176-K240)
Accession # A0A3Q7RTD6/XP_858147
C-term
Protein Length

Partial
Synonyms
Pro-NRG1; Neuregulin-1; ARIA; HRG; NRG1
AA Sequence

SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQK

Predicted Molecular Mass
34 kDa(reduced monomer)
Masse moléculaire

Approximately 37 kDa & 34 kDa, based on SDS-PAGE under reducing conditions.
Pureté

≥ 95%, as determined by reducing SDS-PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)

Neuregulin-1/NRG1 Protein, Canine (65a.a, HEK293, mFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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