1. Natural Products
  2. Plants
  3. Nyssaceae
  4. Camptotheca acuminata Decne.

Camptotheca acuminata Decne.

Camptotheca acuminata Decne. (11):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-16560
    Camptothecin 7689-03-4 99.69%
    Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.
    Camptothecin
  • HY-13768A
    Topotecan Hydrochloride 119413-54-6 99.74%
    Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.
    Topotecan Hydrochloride
  • HY-16562A
    Irinotecan hydrochloride 100286-90-6 99.24%
    Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.
    Irinotecan hydrochloride
  • HY-N0095
    (S)-10-Hydroxycamptothecin 19685-09-7 99.38%
    (S)-10-Hydroxycamptothecin (10-HCPT;10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor of isolated from the Chinese plant Camptotheca accuminata. (S)-10-Hydroxycamptothecin exhibits a remarkable apoptosis-inducing effect. (S)-10-Hydroxycamptothecin has the potential for hepatoma, gastric carcinoma, colon cancer and leukaemia treatment.
    (S)-10-Hydroxycamptothecin
  • HY-N0572
    9-Hydroxycamptothecin 67656-30-8 98.13%
    9-Hydroxycamptothecin (9-Hydroxycamptothecine) is a Camptothecin derivative with anticancer activities extracted from patent WO1999001456A1, compound 23c.
    9-Hydroxycamptothecin
  • HY-100309
    9-amino-CPT 91421-43-1 99.05%
    9-amino-CPT (9-amino-20(S)-camptothecin) is a topoisomerase I inhibitor with potent anticancer activity.
    9-amino-CPT
  • HY-13744
    Rubitecan 91421-42-0 98.07%
    Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells.
    Rubitecan
  • HY-N0275
    (±)-10-Hydroxycamptothecin 64439-81-2 99.44%
    (±)-10-Hydroxycamptothecin is an indole alkaloid that inhibits the activity of topoisomerase I and has a broad spectrum of anticancer activity.
    (±)-10-Hydroxycamptothecin
  • HY-N0446
    10-Methoxycamptothecin 19685-10-0 99.03%
    10-Methoxycamptothecin is a natural bioactive derivative of camptothecin (CPT) isolated from Camptotheca acuminata, and has been confirmed to possess high anti-cancer properties. 10-Methoxycamptothecin has higher cytotoxicity than 10-hydroxycamptothecin by testing antitumor activity against 2774 cell lines.
    10-Methoxycamptothecin
  • HY-N6011
    9-Methoxycamptothecin 39026-92-1 99.41%
    9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer.
    9-Methoxycamptothecin
  • HY-N8533
    Sodium Camptothecin 25387-67-1
    Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.
    Sodium Camptothecin