2. Others Cell Cycle/DNA Damage
  3. Drug Derivative Drug Intermediate Topoisomerase
  4. 7-Ethylcamptothecin

7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies.

For research use only. We do not sell to patients.

7-Ethylcamptothecin

7-Ethylcamptothecin Chemical Structure

CAS No. : 78287-27-1

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Based on 1 publication(s) in Google Scholar

Other Forms of 7-Ethylcamptothecin:

7-Ethylcamptothecin Related Antibodies

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Description

7-Ethylcamptothecin is a derivative of Camptothecin (HY-16560) and a DNA topoisomerase I inhibitor that exhibits significant antitumor activity against tumor cells. 7-Ethylcamptothecin serves as a key precursor for the synthesis of 20 (S)-O-substituted benzoyl-7-ethylcamptothecin compounds. 7-Ethylcamptothecin is widely used in various tumor-related scientific studies[1][2][3].

In Vitro

7-Ethylcamptothecin serves as a starting material for the development of E-ring modified water-soluble camptothecin derivatives, and exhibits favorable antitumor activity[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Ethylcamptothecin Related Antibodies
Molecular Weight

376.41

Formula

C22H20N2O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC=CC=C5N=C4C3=C2)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (13.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6567 mL 13.2834 mL 26.5668 mL
5 mM 0.5313 mL 2.6567 mL 5.3134 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (393 KB)

COA (257 KB) HNMR (200 KB) LCMS (120 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6567 mL 13.2834 mL 26.5668 mL 66.4169 mL
5 mM 0.5313 mL 2.6567 mL 5.3134 mL 13.2834 mL
10 mM 0.2657 mL 1.3283 mL 2.6567 mL 6.6417 mL
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7-Ethylcamptothecin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Ethylcamptothecin78287-27-1Drug DerivativeDrug IntermediateTopoisomeraseDrug derivativeDrug Iintermediatemicetumor cellsDNA topoisomerase ItumorInhibitorinhibitorinhibit

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