1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Rubitecan

Rubitecan (Synonyms: RFS 2000; 9-Nitrocamptothecin)

Cat. No.: HY-13744 Purity: 98.79%
Handling Instructions

Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells.

For research use only. We do not sell to patients.

Rubitecan Chemical Structure

Rubitecan Chemical Structure

CAS No. : 91421-42-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells[1][2][3].

IC50 & Target

Topoisomerase I[1]

In Vitro

Rubitecan (RFS 2000) inhibits U-CH1, U-CH2, and CCL4 cells with IC50s 0.32, 0.83, and 7.7 µM, respectively[4].

Clinical Trial
Molecular Weight

393.35

Formula

C₂₀H₁₅N₃O₆

CAS No.

91421-42-0

SMILES

O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=CC5=C([N+]([O-])=O)C=CC=C5N=C4C3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (317.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5423 mL 12.7113 mL 25.4227 mL
5 mM 0.5085 mL 2.5423 mL 5.0845 mL
10 mM 0.2542 mL 1.2711 mL 2.5423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Rubitecan
Cat. No.:
HY-13744
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