1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Sodium Camptothecin

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.

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Sodium Camptothecin Chemical Structure

Sodium Camptothecin Chemical Structure

CAS No. : 25387-67-1

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Based on 1 publication(s) in Google Scholar

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Description

Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA[1][2].

In Vitro

Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis[1].
Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

388.35

Formula

C20H17N2NaO5

CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C1N2C(C3=NC4=CC=CC=C4C=C3C2)=CC([C@](CC)(O)C(O[Na])=O)=C1CO

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (128.75 mM; Need ultrasonic)

DMSO : 25 mg/mL (64.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5750 mL 12.8750 mL 25.7500 mL
5 mM 0.5150 mL 2.5750 mL 5.1500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.5750 mL 12.8750 mL 25.7500 mL 64.3749 mL
5 mM 0.5150 mL 2.5750 mL 5.1500 mL 12.8750 mL
10 mM 0.2575 mL 1.2875 mL 2.5750 mL 6.4375 mL
15 mM 0.1717 mL 0.8583 mL 1.7167 mL 4.2917 mL
20 mM 0.1287 mL 0.6437 mL 1.2875 mL 3.2187 mL
25 mM 0.1030 mL 0.5150 mL 1.0300 mL 2.5750 mL
30 mM 0.0858 mL 0.4292 mL 0.8583 mL 2.1458 mL
40 mM 0.0644 mL 0.3219 mL 0.6437 mL 1.6094 mL
50 mM 0.0515 mL 0.2575 mL 0.5150 mL 1.2875 mL
60 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0729 mL
H2O 80 mM 0.0322 mL 0.1609 mL 0.3219 mL 0.8047 mL
100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.6437 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sodium Camptothecin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Sodium Camptothecin
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