Sodium Camptothecin
Based on 1 Customer Validation
Sodium Camptothecin is a plant alkaloid, with antitumor activity. Sodium Camptothecin is a reversible inhibitor of RNA synthesis. Sodium Camptothecin is an effective inhibitor of adenovirus replication. Sodium Camptothecin inhibits DNA synthesis and causes breaks in intracellular preformed viral DNA.
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- Purity: 95.0%
- CAS No.: 25387-67-1
- 화학식: C20H17N2NaO5
- 분자량:388.35
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보관:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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All DNA/RNA Synthesis Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
12 μM
Compound: 2a
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Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells
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[PMID: 8410981] |
| L1210 | IC50 |
0.014 μM
Compound: 15
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Concentration that inhibits the proliferation of L1210 cells by 50%
Concentration that inhibits the proliferation of L1210 cells by 50%
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[PMID: 2537428] |
Sodium Camptothecin (5 μM; 10 min) causes a severe inhibition of heterogeneously sedimenting nuclear RNA (HnRNA) synthesis[1].
Sodium Camptothecin also blocks a specific step in the processing of ribosomal precursor RNA, allowing the conversion of 45S RNA to 32S RNA, but inhibiting the conversion of 32S RNA to 28S RNA [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25387-67-1
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Appearance Solid
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분자량 388.35
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화학식 C20H17N2NaO5
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Color Light yellow to brown
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SMILES
O=C1N2C(C3=NC4=CC=CC=C4C=C3C2)=CC([C@](CC)(O)C(O[Na])=O)=C1CO
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
H2O : 50 mg/mL (128.75 mM; Need ultrasonic)
DMSO : 25 mg/mL (64.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (276 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
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- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
[1]. R S Wu, et al. Ribosome formation is blocked by camptothecin, a reversible inhibitor of RNA synthesis. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3009-14. [Content Brief]
[2]. M S Horwitz, et al. Camptothecin: mechanism of inhibition of adenovirus formation. Virology. 1972 Jun;48(3):690-8 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5750 mL | 12.8750 mL | 25.7500 mL | 64.3749 mL |
| 5 mM | 0.5150 mL | 2.5750 mL | 5.1500 mL | 12.8750 mL | |
| 10 mM | 0.2575 mL | 1.2875 mL | 2.5750 mL | 6.4375 mL | |
| 15 mM | 0.1717 mL | 0.8583 mL | 1.7167 mL | 4.2917 mL | |
| 20 mM | 0.1287 mL | 0.6437 mL | 1.2875 mL | 3.2187 mL | |
| 25 mM | 0.1030 mL | 0.5150 mL | 1.0300 mL | 2.5750 mL | |
| 30 mM | 0.0858 mL | 0.4292 mL | 0.8583 mL | 2.1458 mL | |
| 40 mM | 0.0644 mL | 0.3219 mL | 0.6437 mL | 1.6094 mL | |
| 50 mM | 0.0515 mL | 0.2575 mL | 0.5150 mL | 1.2875 mL | |
| 60 mM | 0.0429 mL | 0.2146 mL | 0.4292 mL | 1.0729 mL | |
| H2O | 80 mM | 0.0322 mL | 0.1609 mL | 0.3219 mL | 0.8047 mL |
| 100 mM | 0.0257 mL | 0.1287 mL | 0.2575 mL | 0.6437 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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