2. Anti-infection Membrane Transporter/Ion Channel Apoptosis Stem Cell/Wnt
  3. Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
  4. Monensin sodium

Monensin sodium  (Synonyms: Monensin A sodium)

Cat. No.: HY-N0150 Purity: ≥98.0%
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Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

For research use only. We do not sell to patients.

Monensin sodium Chemical Structure

Monensin sodium Chemical Structure

CAS No. : 22373-78-0

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Solution
10 mM * 1 mL in Ethanol USD 55 In-stock
Solid
100 mg USD 50 In-stock
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Based on 18 publication(s) in Google Scholar

Other Forms of Monensin sodium:

Monensin sodium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects[1][2][3][4].

IC50 & Target

bacterial[1]
In Vitro

Monensin (1-5 μM; 48 h) sodium results in a marked decrease in viability in a dose-dependent manner[1].
Monensin (1-5 μM; 24 h) sodium shows a statistically significant induction of apoptosis[1].
Monensin (0.1-1 μM; 24 h) sodium inhibits pEGFR and its downstream targets pAKT and pERK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Monensin sodium Related Antibodies

Cell Viability Assay[1]

Cell Line: SCC9, SCC25, and GM-38 cell lines
Concentration: 1-5 μM
Incubation Time: 48 h
Result: Resulted in a marked decrease in viability in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: SCC25 cells
Concentration: 1 μM, or 5 μM
Incubation Time: 24 hours
Result: Induced a potent apoptotic response.

Western Blot Analysis[1]

Cell Line: SCC9 and SCC25 cells
Concentration: 0.1 μM, or 1 μM
Incubation Time: 24 hours
Result: Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.
In Vivo

Monensin (10 mg/kg; po; daily; for 6 weeks) sodium suppresses progression of the intestinal tumors without any sign of toxicity on normal mucosa in multiple intestinal neoplasia (Min) mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Multiple intestinal neoplasia (Min) mice (four-week-old) [2]
Dosage: 10 mg/kg
Administration: Orally application; daily; for 6 weeks
Result: Suppressed progression of the intestinal tumors without any sign of toxicity on normal mucosa.
Molecular Weight

692.85

Formula

C36H61NaO11
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@]1(O)[C@H](C)C[C@H](C)[C@]([C@@]2(O[C@]([C@@]3(CC[C@@]([C@]4(O[C@@]5(C[C@H](O)[C@@H](C)[C@@]([H])([C@H]([C@@H](OC)[C@H](C)C(O[Na])=O)C)O5)CC4)C)([H])O3)CC)([H])[C@@H](C)C2)[H])([H])O1
Structure Classification
Initial Source

Streptomyces spp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : 20 mg/mL (28.87 mM; Need ultrasonic)

DMSO : 2 mg/mL (2.89 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4433 mL 7.2166 mL 14.4331 mL
5 mM 0.2887 mL 1.4433 mL 2.8866 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 2 mg/mL (2.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥98.0%

COA (255 KB) HNMR (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 1.4433 mL 7.2166 mL 14.4331 mL 36.0828 mL
Ethanol 5 mM 0.2887 mL 1.4433 mL 2.8866 mL 7.2166 mL
10 mM 0.1443 mL 0.7217 mL 1.4433 mL 3.6083 mL
15 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4055 mL
20 mM 0.0722 mL 0.3608 mL 0.7217 mL 1.8041 mL
25 mM 0.0577 mL 0.2887 mL 0.5773 mL 1.4433 mL
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Monensin sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monensin22373-78-0Monensin ABacterialAntibioticNa+/H+ Exchanger (NHE)ParasiteApoptosisFungalWntSodium/hydrogen ExchangerSodium-hydrogen ExchangerInhibitorinhibitorinhibit

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