2. Others Apoptosis Anti-infection
  3. Fungal Environmental Pollutants Apoptosis
  4. Fludioxonil

Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.

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Fludioxonil

Fludioxonil Chemical Structure

CAS No. : 131341-86-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Fludioxonil:

Fludioxonil Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells[1][2][3][4].

In Vitro

Fludioxonil with EC50 of Fludioxonil for HA61, NT18 and SZ45 are 0.0039, 0.0118 and 0.018 lg/mL[1].
Fludioxonil has a strong inhibitory effect on hyphal growth[1].
Fludioxonil (10 nM-10 μM, 9 days) promots the proliferation of MCF-7 CV cells[2].
Fludioxonil (10 μM, 72 h) reduces the expression of p21 and E-cadherin proteins in MCF-7 CV cells[2].
Fludioxonil (10 μM, 72 h) promotes the migration of MCF-7 CV cells[2].
Fludioxonil inhibits F98 cells with an IC50 of 40μM[3].
Fludioxonil (10-40 μM, 24 h) increases ROS levels in F98 cells and induces lipid peroxidation and cell cycle arrest[3].
Fludioxonil (10-40 μM, 24 h) treatment induces DNA fragmentation in F98 cells[3].
Fludioxonil (10-40 μM, 24 h) treatment induces apoptosis in F98 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fludioxonil Related Antibodies

Cell Viability Assay[2]

Cell Line: MCF-7 CV
Concentration: 10 nM, 1 μM, 10 μM
Incubation Time: 9 days
Result: Promoted cell proliferation.

Western Blot Analysis[2]

Cell Line: MCF-7 CV
Concentration: 10 μM
Incubation Time: 72 h
Result: Reduced p21 expression and significantly increased protein expression of cyclin E1 and cyclin D1.

Cell Migration Assay [2]

Cell Line: MCF-7 CV
Concentration: 10 μM
Incubation Time: 72 h
Result: Enabled significant single-layer wound healing.
In Vivo

Fludioxonil (40 mg/kg, i.g., once every three days for 80 days) inhibits tumor proliferation in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCF-7V-transplanted mice[2]
Dosage: 40 mg/kg; every 3 days; 80 days
Administration: i.g.
Result: Accelerated tumor growth in vivo, and the expression of PCNA in animal tumor tissues also significantly increased.
Molecular Weight

248.19

Formula

C12H6F2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CNC=C1C2=C3OC(F)(F)OC3=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (805.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0292 mL 20.1459 mL 40.2917 mL
5 mM 0.8058 mL 4.0292 mL 8.0583 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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C2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (20.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.94%

SDS (458 KB)

COA (253 KB) HNMR (118 KB) RP-HPLC (197 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0292 mL 20.1459 mL 40.2917 mL 100.7293 mL
5 mM 0.8058 mL 4.0292 mL 8.0583 mL 20.1459 mL
10 mM 0.4029 mL 2.0146 mL 4.0292 mL 10.0729 mL
15 mM 0.2686 mL 1.3431 mL 2.6861 mL 6.7153 mL
20 mM 0.2015 mL 1.0073 mL 2.0146 mL 5.0365 mL
25 mM 0.1612 mL 0.8058 mL 1.6117 mL 4.0292 mL
30 mM 0.1343 mL 0.6715 mL 1.3431 mL 3.3576 mL
40 mM 0.1007 mL 0.5036 mL 1.0073 mL 2.5182 mL
50 mM 0.0806 mL 0.4029 mL 0.8058 mL 2.0146 mL
60 mM 0.0672 mL 0.3358 mL 0.6715 mL 1.6788 mL
80 mM 0.0504 mL 0.2518 mL 0.5036 mL 1.2591 mL
100 mM 0.0403 mL 0.2015 mL 0.4029 mL 1.0073 mL
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Fludioxonil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fludioxonil131341-86-1CGA-173506CGA173506CGA 173506FungalEnvironmental PollutantsApoptosisEnvironmental ContaminantsBactericidaltumor growth promotingapoptosis promotingcardiotoxicInhibitorinhibitorinhibit

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