1643913-93-2
1643913-93-2
Chemical Structure
Padnarsertib
Synonym(s): KPT-9274
- CAS No.: 1643913-93-2
- Formula:C35H29F3N4O3
- Molecular Weight:610.63
IUPAC Name: (E)-3-(6-aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide
InChIKey: MRFOPLWJZULAQD-SWGQDTFXSA-N
SMILES: FC(C=C1)=CC=C1C2=C(OC(CNC(/C=C/C3=CN=C(N)C=C3)=O)=C4)C4=CC(C5=CC=C(C(N6CCC(F)(F)CC6)=O)C=C5)=C2
Biological Activity: Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s of <100 nM and 120 nM, respectively[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Padnarsertib | 99.58% | Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s of <100 nM and 120 nM, respectively. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.45
HY-149890Anticancer agent 130 -
Similarity Score 0.45
HY-160799HA-9104 -
Similarity Score 0.45
HY-147527CDK8-IN-5 -
Similarity Score 0.45
HY-150566BCR-ABL-IN-5 -
Similarity Score 0.44
HY-179348DPP9-IN-2 -
Similarity Score 0.44
HY-109015Tucidinostat -
Similarity Score 0.44
HY-13592HDAC-IN-7 -
Similarity Score 0.44
HY-1837384E1RCat 27d -
Similarity Score 0.43
HY-141836MMV666810 -
Explore the MedChemAI to find more analogs
References
- [1]. WO2015003166A1
- [2]. Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. Mol Cancer Ther. 2016 Sep;15(9):2119-29. [Content Brief]
- [3]. Abu Aboud O, et al. Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth.Mol Cancer Ther. 2016 Sep;15(9):2119-29. [Content Brief]
