2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. BCR-ABL-IN-5

BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells.

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BCR-ABL-IN-5 Chemical Structure

BCR-ABL-IN-5 Chemical Structure

CAS No. : 1795736-60-5

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BCR-ABL-IN-5 Related Antibodies

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Description

BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1].

IC50 & Target

IC50: 6.5 μM (K562)[1].
In Vitro

BCR-ABL-IN-5 (compound II) (0-100 mM, 72 hours) can inhibit the proliferation of K562 human leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BCR-ABL-IN-5 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: K562 human leukemia cell line
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited K562 proliferation with an IC50 value of 6.5 μM.
Molecular Weight

494.37

Formula

C25H21Cl2N5O2
CAS No.
SMILES

NC1=NNC2=C1C(C3=CC=C(C=C3)C(N4CCN(CC4)C(C5=C(C=C(C=C5)Cl)Cl)=O)=O)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BCR-ABL-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCR-ABL-IN-51795736-60-5Bcr-AblBcr-Abl kinase inhibitorBcr-AblT315IleukemiccancerK562 cell linesInhibitorinhibitorinhibit

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