BCR-ABL-IN-5
BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells.
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- CAS No.: 1795736-60-5
- 화학식: C25H21Cl2N5O2
- 분자량:494.37
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
IC50: 6.5 μM (K562)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
6.5 μM
Compound: 11a
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Cytotoxicity against human K562 cells expressing Bcr-Abl assessed as growth inhibition after 48 hrs by MTT assay
Cytotoxicity against human K562 cells expressing Bcr-Abl assessed as growth inhibition after 48 hrs by MTT assay
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[PMID: 26451772] |
BCR-ABL-IN-5 (compound II) (0-100 mM, 72 hours) can inhibit the proliferation of K562 human leukemia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:K562 human leukemia cell line
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Inhibited K562 proliferation with an IC50 value of 6.5 μM.
Chemical Information
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CAS No. 1795736-60-5
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분자량 494.37
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화학식 C25H21Cl2N5O2
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SMILES
NC1=NNC2=C1C(C3=CC=C(C=C3)C(N4CCN(CC4)C(C5=C(C=C(C=C5)Cl)Cl)=O)=O)=CC=C2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCR-ABL-IN-5 Related Classifications
HY-150566 Related Classifications
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