1795736-60-5
1795736-60-5
Chemical Structure
BCR-ABL-IN-5
- CAS. Nr.: 1795736-60-5
- Formula:C25H21Cl2N5O2
- Molecular Weight:494.37
IUPAC Name: (4-(4-(3-amino-1H-indazol-4-yl)benzoyl)piperazin-1-yl)(2,4-dichlorophenyl)methanone
InChIKey: KFUPFXKVTHKTDP-UHFFFAOYSA-N
SMILES: NC1=NNC2=C1C(C3=CC=C(C=C3)C(N4CCN(CC4)C(C5=C(C=C(C=C5)Cl)Cl)=O)=O)=CC=C2
Biological Activity: BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells[1].
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BCR-ABL-IN-5 | BCR-ABL-IN-5 (compound II) is a Bcr-Abl kinase (Breakpoint cluster region-Abelson) inhibitor. BCR-ABL-IN-5 inhibits Bcr-AblWT and Bcr-AblT3151 with the IC50 value of 0.014 μM and 0.45 μM, respectively. BCR-ABL-IN-5 has some anti-proliferative activity against leukemic cells. | |||||||||||||||||||||
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