DPP9-IN-2 

DPP9-IN-2 is a selective, potent and orally active inhibitor of Dipeptidyl Peptidase 9 (DPP9 ) with an IC₅₀ of 12.9 nM. DPP9-IN-2 shows a SI of 59 over DPP8, and shows no significant inhibitory activity against related peptidases including DPP2, DPP4, FAP, and PREP. DPP9-IN-2 can induce cancer cells pyroptosis and has weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitor. DPP9-IN-2 can be used for the researches of cance rand infection^[1].

DPP9-IN-2 (Compound 6e) (0.05-5 μM; 24-48 h) induces pyroptosis in THP-1 cells, promoting LDH release and SYTOX Green uptake ^[1].
DPP9-IN-2 (0.5-5 μM; 24 h) induces pyroptosis depending on DPP9, CASP1, and GSDMD, and pyroptosis is significantly inhibited or delayed in DPP9-knockdown, CASP1-KO, or GSDMD-KO THP-1 cells^[1].
DPP9-IN-2 (5 μM) shows weak synergistic anti-HIV-1 activity when combined with non-nucleoside reverse transcriptase inhibitors (Efavirenz (HY-10572), Rilpivirine (HY-10574)) in MT-4 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DPP9-IN-2 (Compound 6e) (5 mg/kg for i.v. or 20 mg/kg for p.o. ) increases the necrosis rate of CD3⁻CD11b⁻ leukocytes (such as B cells and NK cells) in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

541.63

C₃₃H₃₃F₂N₃O₂

3020859-44-0

O=C(C1=CC=C(C2=CC=C(F)C=C2)C=C1)NC34CC5(NCC(N6CC7=C(C=C(F)C=C7)C6)=O)CC(C4)CC(C5)C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Filippi N, et al. Selective and Orally Bioavailable Dipeptidyl Peptidase 9 Inhibitors with Potent Pyroptosis Induction Properties. J Med Chem. 2025;68(21):23163-23184.  [Content Brief]