200484-11-3
200484-11-3
Chemical Structure
CHS-828
Synonym(s): GMX1778
- CAS No.: 200484-11-3
- Formula:C19H22ClN5O
- Molecular Weight:371.86
InChIKey: BOIPLTNGIAPDBY-UHFFFAOYSA-N
SMILES: N#CN/C(NCCCCCCOC1=CC=C(C=C1)Cl)=N\C2=CC=NC=C2
Biological Activity: CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CHS-828 | 99.76% | CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CHS-828 (Standard) | ≥98% | CHS-828 (Standard) is the analytical standard of CHS-828. This product is intended for research and analytical applications. CHS-828 (GMX1778) is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.79
HY-10079ACHS-828 (nicotinate) -
Similarity Score 0.59
HY-W035403N-(5-(4-Aminophenoxy)pentyl)-2-phenoxyacetamide -
Similarity Score 0.58
HY-W035380N-(5-(4-Aminophenoxy)pentyl)nicotinamide -
Similarity Score 0.58
HY-W4883034,4'-(Hexane-1,6-diylbis(oxy))dibenzonitrile -
Similarity Score 0.57
HY-136081Hexamidine -
Similarity Score 0.56
HY-23317N-Methyl-4-(8-phenoxyoctoxy)aniline -
Similarity Score 0.56
HY-184084Antiparasitic agent-45 -
Similarity Score 0.56
HY-16918Heptamidine -
Similarity Score 0.56
HY-W0354124-((5-(4-Ethoxyphenoxy)pentyl)oxy)aniline -
Explore the MedChemAI to find more analogs
