CHS-828 (nicotinate)
Based on 4 publication(s) in Google Scholar
CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC50 less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD+ and exhibits a potent anticancer activity.
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- CAS No.: 1160589-73-0
- Formula: C25H27ClN6O3
- Molecular Weight:494.97
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) CHS-828 (nicotinate)
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Biological Activity
Chemical Information
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CAS No. 1160589-73-0
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Molecular Weight 494.97
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Formula C25H27ClN6O3
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SMILES
N#CN/C(NCCCCCCOC1=CC=C(C=C1)Cl)=N\C2=CC=NC=C2.O=C(C3=CC=CN=C3)O
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Synonyms
GMX1778 (nicotinate)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Biochem Pharmacol
Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase. [Abstract]2025 Jul:237:116932. PMID: 40189160 -
Clin Transl Sci
Computational drug discovery pipelines identify NAMPT as a therapeutic target in neuroendocrine prostate cancer. [Abstract]2024 Sep;17(9):e70030. PMID: 39295559 -
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Purity & Documentation
References
[1]. Watson M, et al. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol. 2009 Nov;29(21):5872-88. [Content Brief]
[2]. Cerna D, et al. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. J Biol Chem. 2012 Jun 22;287(26):22408-17. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHS-828 (nicotinate) Related Classifications
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