1. Metabolic Enzyme/Protease
  2. NAMPT
  3. Nampt-IN-10 TFA

Nampt-IN-10 TFA 

Cat. No.: HY-147193
Handling Instructions

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs.

For research use only. We do not sell to patients.

Nampt-IN-10 TFA Chemical Structure

Nampt-IN-10 TFA Chemical Structure

CAS No. : 2567724-20-1

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Description

Nampt-IN-10 TFA (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 TFA shows cellular potency to A2780 and CORL23 cells lines with IC50s of 5 and 19 nM, respectively. Nampt-IN-10 TFA can be used as a novel non-antimitotic payload for ADCs[1].

IC50 & Target

IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)[1]

In Vitro

Nampt-IN-10 TFA (0-1 μM; 72 h) shows cellular potency to A2780, CORL23, and c-Kit and HER2 expressing cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines
Concentration: 0-1 μM
Incubation Time: 72 hours
Result: Showed cellular potency towards A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC50 values of 5, 19, 2, 0.4 and 1 nM, respectively.
Formula

C29H29F4N5O4

CAS No.
SMILES

OC(C(F)(F)F)=O.FC(C=C1NC([[email protected]@H]2[[email protected]@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O.[F,Cl,Br,I]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Nampt-IN-10 TFA
Cat. No.:
HY-147193
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