2237268-08-3
Chemical Structure
SBI-797812
- CAS No.: 2237268-08-3
- Formula:C19H22N4O4S
- Molecular Weight:402.47
IUPAC Name: 1-(4-((8-oxa-3-azabicyclo[3.2.1]octan-3-yl)sulfonyl)phenyl)-3-(pyridin-4-ylmethyl)urea
InChIKey: KTSOHNHLOLGQCY-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CC(O4)CCC4C3)=O)C=C2
Biological Activity: SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SBI-797812 | 99.88% | SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice. | ||||||||||||||||||||
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Similarity Score 0.73
HY-163445NAMPT activator-6 -
Similarity Score 0.58
HY-183148NAMPT activator-10 -
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HY-162269Nampt activator-5 -
Similarity Score 0.56
HY-148815Nampt activator-1 -
Similarity Score 0.55
HY-148429Antimalarial agent 17 -
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HY-123833PF-05661014 -
Similarity Score 0.54
HY-172919PDEδ/NAMPT IN-1 -
Similarity Score 0.54
HY-159009MS7 -
Similarity Score 0.53
HY-171007IRF1-IN-2 -
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References
- [1]. Gardell SJ , et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat Commun. 2019 Jul 19;10(1):3241. [Content Brief]
- [2]. Khaidizar FD, et al. Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. Int J Mol Sci. 2021 Apr 2;22(7):3709. [Content Brief]
