Antimalarial agent 17

Name: Antimalarial agent 17
Brand: MedChemExpress
SKU: HY-148429
Rating: 4.5 (0 reviews)

Cat. No.: HY-148429 Purity: 99.51%: Data Sheet
COA

SDS
Handling Instructions
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Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides.

For research use only. We do not sell to patients.

Antimalarial agent 17 Chemical Structure

CAS No. : 508187-76-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Antimalarial agent 17 is an antimalarial agent, also acts as a herbicide. Antimalarial agent 17 is photosystem II inhibitor, shows post-emergence herbicidal activity equal to commercial herbicides^[1].

IC₅₀ & Target

Plasmodium

In Vitro

Antimalarial agent 17 (compound 7) (25, 50, 100, 200, 400 mg/L; post-emergence) shows a potent post-emergence herbicidal activity against A. thaliana. seedlings^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

392.90

Formula

C₁₉H₂₁ClN₂O₃S

CAS No.

508187-76-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CCN(S(=O)(C2=CC=C(C=C2)Cl)=O)CC1)NCC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (254.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5452 mL	12.7259 mL	25.4518 mL
5 mM	0.5090 mL	2.5452 mL	5.0904 mL
10 mM	0.2545 mL	1.2726 mL	2.5452 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.51%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (246 KB) HNMR (259 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Corral MG, et al. Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides. Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9881-9885. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5452 mL	12.7259 mL	25.4518 mL	63.6294 mL
	5 mM	0.5090 mL	2.5452 mL	5.0904 mL	12.7259 mL
	10 mM	0.2545 mL	1.2726 mL	2.5452 mL	6.3629 mL
	15 mM	0.1697 mL	0.8484 mL	1.6968 mL	4.2420 mL
	20 mM	0.1273 mL	0.6363 mL	1.2726 mL	3.1815 mL
	25 mM	0.1018 mL	0.5090 mL	1.0181 mL	2.5452 mL
	30 mM	0.0848 mL	0.4242 mL	0.8484 mL	2.1210 mL
	40 mM	0.0636 mL	0.3181 mL	0.6363 mL	1.5907 mL
	50 mM	0.0509 mL	0.2545 mL	0.5090 mL	1.2726 mL
	60 mM	0.0424 mL	0.2121 mL	0.4242 mL	1.0605 mL
	80 mM	0.0318 mL	0.1591 mL	0.3181 mL	0.7954 mL
	100 mM	0.0255 mL	0.1273 mL	0.2545 mL	0.6363 mL