2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Nampt activator-5

Nampt activator-5 is a NAMPT activator with a KD value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD+ biosynthesis and promotes NAD+ production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of *Caenorhabditis elegans*, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research.

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Nampt activator-5

Nampt activator-5 Chemical Structure

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Nampt activator-5 Related Antibodies

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Description

Nampt activator-5 is a NAMPT activator with a KD value of 6.19 μM. Nampt activator-5 activates the rate-limiting enzyme in NAD+ biosynthesis and promotes NAD+ production. Nampt activator-5 delays the senescence process of senescent hepatocytes, extends the lifespan of *Caenorhabditis elegans*, and alleviates age-related dysfunction and abnormal biomarkers in naturally aged mice. Nampt activator-5 can be used in aging research[1].

Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
282.7 μM
Compound: C8
Cytotoxicity against HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
Cytotoxicity against HUVEC cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
[PMID: 38367219]
In Vitro

Nampt activator-5 (Compound C8) (0-12 μM) increases intracellular NAD+ levels in A549 cells to 184% at 10 μM, with levels rising in a concentration-dependent manner[1].
Nampt activator-5 increases intracellular NAD+ levels in HEK-293T cells in a concentration-dependent manner[1].
Nampt activator-5 (72 h) exhibits minimal cytotoxicity in HUVEC cells with an IC50 of 282.7 μM after 72 h, and antagonizes FK866-induced cytotoxicity[1].
Nampt activator-5 (20 μM; 24 h) effectively improves lysosomal senescence in Doxorubicin (HY-15142A)-induced senescent HL-7702 cells, normalizing the red/green fluorescence ratio to match young HL-7702 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nampt activator-5 Related Antibodies
In Vivo

Nampt activator-5 (compound C8) (100 μM; incorporation into NGM growth medium; continuous exposure) significantly extends the mean lifespan of wild-type C. elegans by 8.37%[1].
Nampt activator-5 (20 mg/kg; i.p.; every 2 days; 2 months) improves age-related physical dysfunctions, reduces senescence biomarkers, and increases brain NAD+ levels in naturally aged female C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type N2[1]
Dosage: 100 μM
Administration: incorporation into NGM growth medium; continuous exposure
Result: Extended the mean lifespan of C.
elegans by 8.37% compared to the control group, with a statistically significant difference.
Animal Model: C57BL/6J (female, 20-month-old, naturally aged)[1]
Dosage: 20 mg/kg
Administration: i.p.; every 2 days; 2 months
Result: Improved muscle strength (grip strength/body weight ratio), hanging endurance (suspension duration × body weight), rotarod performance (running time, distance, maximum speed) compared to aged control mice, with results approaching those of young control mice.
Significantly reduced serum levels of CXCL1, IL-1β, MMP-1, p21, and p53 compared to aged control mice.
Reduced protein levels of p21, p53, and γ-H2AX in kidney tissue compared to aged control mice.
Significantly elevated NAD+ levels in the brain compared to aged control mice.
Molecular Weight

432.44

Formula

C20H18F2N4O3S
SMILES

O=C(NCC1=CC=NC=C1)NC2=CC=C(S(NCC3=C(C=CC(F)=C3)F)(=O)=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nampt activator-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt activator-5Nampt activator5Nampt activator 5NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorsenescent liver cellsHUVEC cellsnaturally aging miceNAD+HEK-293T cellsA549 cellsHL-7702 cellsCaenorhabditis elegansC57BL/6J miceInhibitorinhibitorinhibit

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