2790481-63-7
Chemical Structure
Nampt activator-3
- CAS. Nr.: 2790481-63-7
- Formula:C19H20N2O3
- Molecular Weight:324.37
IUPAC Name: 2-(2-(tert-butyl)-6-cyanophenoxy)-N-(4-hydroxyphenyl)acetamide
InChIKey: VKGWHNRIOPYZTC-UHFFFAOYSA-N
SMILES: N#CC1=CC=CC(C(C)(C)C)=C1OCC(NC2=CC=C(C=C2)O)=O
Biological Activity: NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity[1].
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Nampt activator-3 | 99.71% | NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM. NAMPT activator-3 effectively protects cultured cells from FK866 (HY-50876)-mediated toxicity. NAMPT activator-3 exhibits strong neuroprotective efficacy in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model without any overt toxicity. | ||||||||||||||||||||
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Keywords
