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Cat. No.: HY-184247

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SR-32685

SR-32685 is a NAMPT activator and neuroprotective agent. SR-32685 enhances the enzymatic activity of hNAMPT, prevents intracellular NAD depletion, and protects neurons from death induced by toxic misfolded prion proteins. SR-32685 can be used in the research of protein misfolding neurodegenerative diseases and metabolic diseases.

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CAS No.: 2791469-14-0
화학식: C₂₂H₂₄N₆O₂S
분자량:436.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR-32685 Chemical Structure

CAS No.: 2791469-14-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
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Biological Activity

제품 설명

In Vitro

SR-32685 protects neuronal cells against TPrP-induced death with an EC₅₀ of 40 nM^[1].
SR-32685 (1 μM) increases the activity of h-NAMPT by at least 10% at a concentration of 1 μM^[1].
SR-32685 exhibits a stability of more than 15 min in h-microsome (liver)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2791469-14-0
분자량 436.53
화학식 C₂₂H₂₄N₆O₂S
SMILES

O=C(C(C=NN12)=C2NC(C3=CC=C(OCC)C=C3)=CC1=S)NCCCN4C=CN=C4C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Thomas D. Bannister, et al. Compounds and use thereof for treatment of neurodegenerative, degenerative and metabolic disorders. WO2022133303A1. WIPO (PCT). 2021-12-17.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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