894187-61-2
894187-61-2
Chemical Structure
STF-118804
- CAS No.: 894187-61-2
- Formula:C25H23N3O4S
- Molecular Weight:461.54
IUPAC Name: 4-(5-methyl-4-(tosylmethyl)oxazol-2-yl)-N-(pyridin-3-ylmethyl)benzamide
InChIKey: DLFCEZOMHBPDGI-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=CN=C1)C2=CC=C(C3=NC(CS(=O)(C4=CC=C(C)C=C4)=O)=C(C)O3)C=C2
Biological Activity: STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer[1][2].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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STF-118804 | 98.49% | STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.59
HY-155949Bt354 -
Similarity Score 0.58
HY-180866GRIN2A modulator-1 -
Similarity Score 0.56
HY-187006Nampt-IN-21 -
Similarity Score 0.56
HY-153681β-Catenin modulator-4 -
Similarity Score 0.54
HY-152156Tubulin inhibitor 11 -
Similarity Score 0.51
HY-153680β-Catenin modulator-3 -
Similarity Score 0.51
HY-153679β-Catenin modulator-2 -
Similarity Score 0.51
HY-114924LY465608 -
Similarity Score 0.50
HY-120160ADarglitazone Sodium -
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References
- [1]. Espindola-Netto JM, et al. Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer. Oncotarget. 2017 Jun 29;8(49):85054-85067. [Content Brief]
- [2]. Matheny CJ, et al. Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol. 2013 Nov 21;20(11):1352-63. [Content Brief]
