1362151-42-5
1362151-42-5
Chemical Structure
GNE-618
- CAS No.: 1362151-42-5
- Formula:C21H15F3N4O3S
- Molecular Weight:460.43
IUPAC Name: N-(4-((3-(trifluoromethyl)phenyl)sulfonyl)benzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
InChIKey: LKBHAGGICJWHQQ-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(S(=O)(C2=CC(C(F)(F)F)=CC=C2)=O)C=C1)C3=CC(C=NN4)=C4N=C3
Biological Activity: GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GNE-618 | 99.89% | GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
