831243-31-3
831243-31-3
Chemical Structure
NAT
- CAS No.: 831243-31-3
- Formula:C18H21NO3
- Molecular Weight:299.36
IUPAC Name: 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(4,5-dihydro-2H-imidazo[2',1':2,3]thiazolo[4,5-e]isoindol-8-yl)phenyl)urea
InChIKey: RUNXUUCDTNJFME-UHFFFAOYSA-N
SMILES: CC(C)(C1=C(C=CC=C1)OCC(NC2=CC=C(C=C2)O)=O)C
Biological Activity: NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases[1].
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NAT | 99.85% | NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases. | ||||||||||||||||||||
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References
Keywords
