831243-31-3

NAT Chemical Structure
831243-31-3

Chemical Structure

NAT

  • CAS No.: 831243-31-3
  • Formula:C18H21NO3
  • Molecular Weight:299.36

IUPAC Name: 1-(5-(tert-butyl)isoxazol-3-yl)-3-(4-(4,5-dihydro-2H-imidazo[2',1':2,3]thiazolo[4,5-e]isoindol-8-yl)phenyl)urea

InChIKey: RUNXUUCDTNJFME-UHFFFAOYSA-N

SMILES: CC(C)(C1=C(C=CC=C1)OCC(NC2=CC=C(C=C2)O)=O)C

Biological Activity: NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases[1].

Cat. No. Product Name Purity Description Pricing
HY-144776 		NAT 99.85% NAT is an initial hit of NAMPT activator with an EC50 of 5.7 μM and a KD of 379 nM. NAMPT is the rate-limiting enzyme in the NAD salvage pathway, which makes it an attractive target for the research of many diseases associated with NAD exhaustion such as neurodegenerative diseases.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

References

Keywords