Domain2_JAK2
This product supplies the isolated domain 2 (JH2 pseudokinase domain) of Janus kinase 2 as a recombinant protein. JH2 lacks canonical catalytic activity yet governs the output of the adjacent JH1 kinase, and its dysregulation is central to myeloid disease: pseudokinase-domain mutations are found in myeloproliferative neoplasms and are thought to release the autoinhibitory constraint that JH2 imposes on JH1. The construct is useful for binding assays, biophysical characterization and inhibitor discovery aimed at this allosteric pseudokinase interface. Full-length JAK2 mediates signaling from the erythropoietin, thrombopoietin and growth hormone receptors, making its regulatory domains particularly relevant to hematology-focused drug development.
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Domain2_JAK2 Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
