Domain2_JAK1
Domain2_JAK1 is a recombinant construct comprising domain 2, the JH2 pseudokinase module, of Janus kinase 1. In full-length JAK1 the FERM-SH2 region and the JH2 pseudokinase lie amino-terminal to the active JH1 kinase domain; JH2 exerts autoinhibitory control over catalytic output while also contributing to cytokine receptor docking. Because pseudokinase domains are emerging allosteric drug-binding sites, this isolated module provides a defined reagent for dissecting intramolecular JAK1 regulation and for screening compounds that engage non-catalytic surfaces. JAK1 itself pairs with JAK2, JAK3 or TYK2 at receptors for interferons and interleukins such as IL-6, signaling through STAT transcription factors.
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Domain2_JAK1 Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
