Domain2_JAK3
Domain2_JAK3 contains the JH2 pseudokinase region of Janus kinase 3, the family member expressed almost exclusively in hematopoietic cells. JAK3 obligatorily associates with the common γ chain shared by the receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, where it couples with JAK1 to activate STAT5 and related pathways that control lymphocyte development and function. Within the receptor complex the pseudokinase domain acts as an intramolecular brake on the JH1 kinase and helps position JAK3 for trans-activation. The isolated domain 2 protein therefore supports structure-function studies of this regulation and screening of compounds selective for the JAK3 pseudokinase surface.
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Domain2_JAK3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
