Domain2_TYK2
TYK2 domain 2, the JH2 pseudokinase module of tyrosine kinase 2, is offered here as a standalone recombinant protein. This region gained prominence as the allosteric site exploited by selective TYK2 inhibitors in psoriasis and other immune-mediated diseases; such compounds stabilize the pseudokinase fold and indirectly shut down catalysis by the adjacent JH1 domain. Full-length TYK2 pairs with JAK1 or JAK2 downstream of the type I interferon, IL-12 and IL-23 receptors and signals predominantly through STAT1, STAT3 and STAT4. The isolated domain is a valuable reagent for selectivity profiling, structural work and assays that distinguish pseudokinase-directed from ATP-competitive compounds.
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Domain2_TYK2 Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
