1. Anti-infection
    Metabolic Enzyme/Protease
  2. Bacterial
    Aminoacyl-tRNA Synthetase
  3. GlyRS-IN-1

GlyRS-IN-1 

Cat. No.: HY-108940 Purity: 97.35%
Handling Instructions

GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria.

For research use only. We do not sell to patients.

GlyRS-IN-1 Chemical Structure

GlyRS-IN-1 Chemical Structure

CAS No. : 112921-11-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 628 In-stock
Estimated Time of Arrival: December 31
5 mg USD 708 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1068 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1. GlyRS-IN-1 can also inhibit the growth of bacteria.

IC50 & Target

GlyRS[1], Bacterial[1]

Molecular Weight

403.37

Formula

C₁₂H₁₇N₇O₇S

CAS No.

112921-11-6

SMILES

O[[email protected]@H]1[[email protected]@H](COS(=O)(NC(CN)=O)=O)O[[email protected]@H](N2C(N=CN=C3N)=C3N=C2)[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (247.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4791 mL 12.3956 mL 24.7911 mL
5 mM 0.4958 mL 2.4791 mL 4.9582 mL
10 mM 0.2479 mL 1.2396 mL 2.4791 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.14 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (4.14 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (4.14 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

GlyRS-IN-1BacterialAminoacyl-tRNA SynthetasetRNA Synthetase, aaRSInhibitorinhibitorinhibit

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Product name:
GlyRS-IN-1
Cat. No.:
HY-108940
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