1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Mupirocin

Mupirocin (Synonyms: BRL-4910A; Pseudomonic acid)

Cat. No.: HY-B0958 Purity: 98.07%
Handling Instructions

Mupirocin (BRL-4910A) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin (BRL-4910A) apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.

For research use only. We do not sell to patients.

Mupirocin Chemical Structure

Mupirocin Chemical Structure

CAS No. : 12650-69-0

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10 mM * 1  mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
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50 mg USD 168 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Mupirocin (BRL-4910A) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin (BRL-4910A) apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].

In Vitro

Mupirocin (BRL-4910A) shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin (BRL-4910A) is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum[1].

In Vivo

Mupirocin is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].

Clinical Trial
Molecular Weight

500.62

Formula

C₂₆H₄₄O₉

CAS No.

12650-69-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (199.75 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9975 mL 9.9876 mL 19.9752 mL
5 mM 0.3995 mL 1.9975 mL 3.9950 mL
10 mM 0.1998 mL 0.9988 mL 1.9975 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MupirocinBRL-4910APseudomonic acidBacterialAntibioticInhibitorinhibitorinhibit

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Mupirocin
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