1596-64-1
Chemical Structure
L-Histidinol dihydrochloride
- CAS No.: 1596-64-1
- Formula:C6H13Cl2N3O
- Molecular Weight:214.10
IUPAC Name: (S)-2-amino-3-(1H-imidazol-4-yl)propan-1-ol dihydrochloride
InChIKey: FRCAFNBBXRWXQA-XRIGFGBMSA-N
SMILES: N[C@@H](CC1=CNC=N1)CO.Cl.Cl
Biological Activity: L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents[1][2][3][4][5][6][7][8][9][10].
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L-Histidinol dihydrochloride | 99.97% | L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents. | ||||||||||||||||||||
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L-Histidinol dihydrochloride (Standard) | ≥98% | L-Histidinol (dihydrochloride) (Standard) is the analytical standard of L-Histidinol (dihydrochloride) (HY-W014233). This product is intended for research and analytical applications. L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents. | ||||||||||||||||||||
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- [1]. Kohnoe S, et al. L-histidinol potentiates hyperthermic cell-killing in-vitro. Int J Oncol. 1993 Nov;3(5):835-9. [Content Brief]
- [2]. https://pubmed.ncbi.nlm.nih.gov/21573440/ [Content Brief]
- [3]. Warrington RC, et al. Effects of L-histidinol on the susceptibility of P815 mastocytoma cells to selected anticancer drugs in vitro and in DBA/2J mice. J Natl Cancer Inst. 1987 Jun;78(6):1177-83. [Content Brief]
- [4]. Warrington RC, et al. Reversal of the multidrug-resistant phenotype of Chinese hamster ovary cells by L-histidinol. J Natl Cancer Inst. 1989 May 10;81(10):798-803. doi: 10.1093/jnci/81.10.798. [Content Brief]
- [5]. Warrington RC, et al. L-histidinol protection against cytotoxic action of cytosine arabinoside and 5-fluorouracil in cultured mouse spleen cells. J Natl Cancer Inst. 1982 Feb;68(2):279-86. [Content Brief]
- [6]. Zaharko D, et al. L-histidinol: preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice. Cancer Res. 1992 Jul 1;52(13):3604-9. [Content Brief]
- [7]. Stolfi RL, et al. Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors. Chemotherapy. 1990;36(6):435-40. [Content Brief]
- [8]. Badary OA, et al. Effect of L-histidinol on cisplatin nephrotoxicity in the rat. Nephron. 1997;77(4):435-9. [Content Brief]
- [9]. Badary OA. L-Histidinol attenuates Fanconi syndrome induced by ifosfamide in rats. Exp Nephrol. 1999 Jul-Aug;7(4):323-7. [Content Brief]
- [10]. Warrington RC, et al. L-histidinol improves the selectivity and efficacy of alkylating agents and daunomycin in mice with P388 leukaemia. Br J Cancer. 1989 Nov;60(5):652-6. [Content Brief]
