2421117-94-2
Chemical Structure
BC-DXI-495
- CAS No.: 2421117-94-2
- Formula:C28H30N4O4S
- Molecular Weight:518.63
InChIKey: JEZKLTVUYPYMPE-MHZLTWQESA-N
SMILES: O=S(N[C@H](C(NC1=CC=C(N2CCOCC2)C=C1)=O)CC3=CNC4=CC=CC=C34)(C5=CC=C(C=C5)C)=O
Biological Activity: BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research[1].
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BC-DXI-495 | BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research. | |||||||||||||||||||||
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Keywords
