BC-DXI-495
Based on 1 Customer Validation
BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 2421117-94-2
- Formula: C28H30N4O4S
- Molecular Weight:518.63
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
14.2 μM
Compound: 2; BC-DXI-495
|
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
|
[PMID: 32315177] |
BC-DXI-495 (Compound 2) inhibits the level of NanoLuciferase-tagged DX2 by 67.10%[1].
BC-DXI-495 inhibits the degradation of DX2 protein, with an IC50 value of 4.20 μM[1].
BC-DXI-495 (72 h) inhibits the viability of A549 lung cancer cells with an EC50 of 14.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2421117-94-2
-
Appearance Solid
-
Molecular Weight 518.63
-
Formula C28H30N4O4S
-
Color White to off-white
-
SMILES
O=S(N[C@H](C(NC1=CC=C(N2CCOCC2)C=C1)=O)CC3=CNC4=CC=CC=C34)(C5=CC=C(C=C5)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (96.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9282 mL | 9.6408 mL | 19.2816 mL | 48.2039 mL |
| 5 mM | 0.3856 mL | 1.9282 mL | 3.8563 mL | 9.6408 mL | |
| 10 mM | 0.1928 mL | 0.9641 mL | 1.9282 mL | 4.8204 mL | |
| 15 mM | 0.1285 mL | 0.6427 mL | 1.2854 mL | 3.2136 mL | |
| 20 mM | 0.0964 mL | 0.4820 mL | 0.9641 mL | 2.4102 mL | |
| 25 mM | 0.0771 mL | 0.3856 mL | 0.7713 mL | 1.9282 mL | |
| 30 mM | 0.0643 mL | 0.3214 mL | 0.6427 mL | 1.6068 mL | |
| 40 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2051 mL | |
| 50 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9641 mL | |
| 60 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8034 mL | |
| 80 mM | 0.0241 mL | 0.1205 mL | 0.2410 mL | 0.6025 mL |
BC-DXI-495 Related Classifications
HY-182399 Related Classifications
Powered by Bioz