BC-DXI-495
BC-DXI-495 is a AIMP2-DX2 inhibitor. BC-DXI-495 disrupts the interaction of HSP70 and destabilizes DX2. BC-DXI-495 induces DX2 degradation via Siah1-mediated ubiquitination. BC-DXI-495 exerts tumor suppressive activity in cancer cells. BC-DXI-495 serves as a chemical probe to elucidate the mechanism of action of arylsulfonamide-based DX2 inhibitors. BC-DXI-495 can be used in lung cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2421117-94-2
- Formula: C28H30N4O4S
- Molecular Weight:518.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
14.2 μM
Compound: 2; BC-DXI-495
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Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay
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[PMID: 32315177] |
BC-DXI-495 (Compound 2) inhibits the level of NanoLuciferase-tagged DX2 by 67.10%[1].
BC-DXI-495 inhibits the degradation of DX2 protein, with an IC50 value of 4.20 μM[1].
BC-DXI-495 (72 h) inhibits the viability of A549 lung cancer cells with an EC50 of 14.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2421117-94-2
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Molecular Weight 518.63
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Formula C28H30N4O4S
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SMILES
O=S(N[C@H](C(NC1=CC=C(N2CCOCC2)C=C1)=O)CC3=CNC4=CC=CC=C34)(C5=CC=C(C=C5)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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