1. Metabolic Enzyme/Protease
    Anti-infection
  2. Aminoacyl-tRNA Synthetase
    Bacterial
  3. Leu-AMS

Leu-AMS 

Cat. No.: HY-108900 Purity: 99.14%
Handling Instructions

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria.

For research use only. We do not sell to patients.

Leu-AMS Chemical Structure

Leu-AMS Chemical Structure

CAS No. : 288591-93-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 716 In-stock
Estimated Time of Arrival: December 31
1 mg USD 228 In-stock
Estimated Time of Arrival: December 31
5 mg USD 708 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1068 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria[1].

IC50 & Target

IC50: 22.34 nM (LRS)[1]

In Vitro

Leu-AMS is proved to be a potent inhibitor of Leucyl-tRNA Synthetase (LRS) with an IC50 value of 22.34 nM. Leu-AMS is highly cytotoxic in both cancer cells and normal cells. Leu-AMS does not affect S6 kinase (S6K) phosphorylation at all. Leu-AMS inhibits the catalytic activity of LRS but does not affect the leucine-induced mTORC1 activation[1].

Molecular Weight

459.48

Formula

C₁₆H₂₅N₇O₇S

CAS No.

288591-93-5

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3COS(=O)(NC([[email protected]@H](N)CC(C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 49.17 mg/mL (107.01 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1764 mL 10.8819 mL 21.7637 mL
5 mM 0.4353 mL 2.1764 mL 4.3527 mL
10 mM 0.2176 mL 1.0882 mL 2.1764 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.14%

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Keywords:

Leu-AMSAminoacyl-tRNA SynthetaseBacterialtRNA Synthetase, aaRSInhibitorinhibitorinhibit

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Leu-AMS
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HY-108900
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