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FB23 

Cat. No.: HY-137187 Purity: 99.49%
Handling Instructions

FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.

For research use only. We do not sell to patients.

FB23 Chemical Structure

FB23 Chemical Structure

CAS No. : 2243736-35-6

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5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 220 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
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50 mg USD 700 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

FB23 is a potent and selective FTO demethylase inhibitor with an IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity[1].

IC50 & Target

IC50: 60 nM (FTO)[1]

In Vitro

FB23 (72 hours) treatment inhibits acute myeloid leukemia (AML) cells proliferation with IC50 values of 44.8 μM, 23.6 μM for NB4 and MONOMAC6 AML cells[1].
FB23 treatment causes the significant suppression of MYC targets, E2F targets, and G2M checkpoint signal cascades, which may contribute to the inhibitory effects of FTO inhibitors and FTO KD on cell cycle and proliferation. FB23 treatments activates apoptosis and p53 pathways[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A single dose of 3 mg/kg FB23 is i.p. administrated to Sprague Dawley (SD) rats for the pharmacokinetic profile. The Cmax and Tmax value of FB23 are 142.5 ng/mL and 0.4 hr, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

377.22

Formula

C₁₈H₁₄Cl₂N₂O₃

CAS No.

2243736-35-6

SMILES

O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (331.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6510 mL 13.2549 mL 26.5097 mL
5 mM 0.5302 mL 2.6510 mL 5.3019 mL
10 mM 0.2651 mL 1.3255 mL 2.6510 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

FB23FB 23FB-23OthersFTON6-methyladenosinedemethylaseleukemogenesisanti-proliferativeInhibitorinhibitorinhibit

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