1. Cytoskeleton
  2. Gap Junction Protein
  3. Gap 26

Gap 26 

Cat. No.: HY-P1082 Purity: 99.30%
Handling Instructions

Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Gap 26 Chemical Structure

Gap 26 Chemical Structure

CAS No. : 197250-15-0

Size Price Stock Quantity
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

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Description

Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

IC50 & Target

Gap Junction Protein[1]

In Vitro

Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].

Storage
Protect from light
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (32.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6448 mL 3.2242 mL 6.4484 mL
5 mM 0.1290 mL 0.6448 mL 1.2897 mL
10 mM 0.0645 mL 0.3224 mL 0.6448 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1550.78

Formula

C₇₀H₁₀₆N₁₉O₁₉S

CAS No.

197250-15-0

Sequence

Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg

Sequence Shortening

VCYDKSFPISHVR

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Gap 26
Cat. No.:
HY-P1082
Quantity:

Gap 26

Cat. No.: HY-P1082