1. Cytoskeleton
  2. Gap Junction Protein
  3. Gap 26 TFA

Gap 26 TFA 

Cat. No.: HY-P1082A Purity: 99.03%
Handling Instructions

Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Gap 26 TFA Chemical Structure

Gap 26 TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif[1].

In Vitro

Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected[1].
Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used[1].
Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1664.80

Formula

C₇₂H₁₀₈F₃N₁₉O₂₁S

Sequence Shortening

VCYDKSFPISHVR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

Gap 26Gap26Gap-26Gap Junction ProteinInhibitorinhibitorinhibit

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Gap 26 TFA
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HY-P1082A
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