1. Cytoskeleton
  2. Gap Junction Protein
  3. AT-1002 TFA

AT-1002 TFA 

Cat. No.: HY-114426A Purity: 99.72%
Handling Instructions

AT-1002 TFA, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.

For research use only. We do not sell to patients.

AT-1002 TFA Chemical Structure

AT-1002 TFA Chemical Structure

Size Price Stock
5 mg USD 250 Get quote
10 mg USD 450 Get quote
50 mg USD 1350 Get quote
100 mg USD 2100 Get quote

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Description

AT-1002 TFA, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].

In Vitro

AT-1002, a 6-mer synthetic peptide, belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1].
Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2].

Cell Viability Assay[2]

Cell Line: Caco-2 cells
Concentration: 0 to 5 mg/mL
Incubation Time: 3 or 24 hours
Result: Treatment for up to 3 h did not affect cell viability at any concentration. Reduced cell viability after 24 h at concentrations of 2.5 mg/mL and higher.
References
Molecular Weight

821.91

Formula

C₃₄H₅₄F₃N₉O₉S

SMILES

N[[email protected]@H](CC1=CC=CC=C1)C(N[[email protected]@H](CS)C(N[[email protected]@H]([[email protected]](CC)C)C(NCC(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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C1   V1   C2   V2

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Product Name:
AT-1002 TFA
Cat. No.:
HY-114426A
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AT-1002 TFA

Cat. No.: HY-114426A