1. Cytoskeleton
  2. Gap Junction Protein

AT-1002 

Cat. No.: HY-114426
Handling Instructions

AT-1002, a 6-mer synthetic peptide, is a tight junction regulator and absorption enhancer.

For research use only. We do not sell to patients.

AT-1002 Chemical Structure

AT-1002 Chemical Structure

CAS No. : 835872-35-0

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2].

In Vitro

AT-1002, a 6-mer synthetic peptide, belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. AT-1002 can undergo Cys-Cys dimerization[1].
Undifferentiated Caco-2 cells are treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours) and viability is assessed by measuring cellular ATP content. Treatment with AT-1002 for up to 3 h does not affect cell viability at any concentration. In particular, the viability of Caco-2 cells is not affected by 5 mg/mL AT-1002. AT-1002 reduces cell viability after 24 h at concentrations of 2.5 mg/mL and higher. However, the cells remain viable after 24 h if the cells are washed after exposure to AT-1002 for 3 h indicating that AT-1002 does not irreversibly damage cells[2].

Cell Viability Assay[2]

Cell Line: Caco-2 cells
Concentration: 0 to 5 mg/mL
Incubation Time: 3 or 24 hours
Result: Treatment for up to 3 h did not affect cell viability at any concentration. Reduced cell viability after 24 h at concentrations of 2.5 mg/mL and higher.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4127 mL 7.0633 mL 14.1267 mL
5 mM 0.2825 mL 1.4127 mL 2.8253 mL
10 mM 0.1413 mL 0.7063 mL 1.4127 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

707.88

Formula

C₃₂H₅₃N₉O₇S

CAS No.

835872-35-0

SMILES

N[[email protected]@H](CC1=CC=CC=C1)C(N[[email protected]@H](CS)C(N[[email protected]@H]([[email protected]](CC)C)C(NCC(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
C1   V1   C2   V2

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Product Name:
AT-1002
Cat. No.:
HY-114426
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AT-1002

Cat. No.: HY-114426