Structure-activity relationship studies of permeability modulating peptide AT-1002

  • Bioorg Med Chem Lett. 2008 Aug 15;18(16):4584-6. doi: 10.1016/j.bmcl.2008.07.028.
Min Li  1 ,  Ed Oliver ,  Kelly M Kitchens ,  John Vere ,  Sefik S Alkan ,  Amir P Tamiz
Affiliations
  • 1. Alba Therapeutics Corporation, 800 West Baltimore Street, Suite 400, Baltimore, MD 21201, USA.
PMID: 18667315 DOI: 10.1016/j.bmcl.2008.07.028
Abstract

AT-1002 a 6-mer synthetic peptide belongs to an emerging novel class of compounds that reversibly increase paracellular transport of molecules across the epithelial barrier. The aim of this project was to elaborate on the structure-activity relationship of this peptide with the specific goal to replace the P2 cysteine amino acid. Herein, we report the discovery of peptides that exhibit reversible permeability enhancement properties with an increased stability profile.

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