1840896-10-7
Chemical Structure
Cx43 HC-IN-1
- CAS No.: 1840896-10-7
- Formula:C24H16ClNO3
- Molecular Weight:401.84
IUPAC Name: (R)-2-(4-chlorophenyl)-2-oxo-1-phenylethyl quinoline-2-carboxylate
InChIKey: WOKCOSHBOZBKRP-HSZRJFAPSA-N
SMILES: O=C(C1=CC=C(C=C1)Cl)[C@@H](C2=CC=CC=C2)OC(C3=NC4=C(C=CC=C4)C=C3)=O
Biological Activity: Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels (Cx43 HC). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases[1][2].
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Cx43 HC-IN-1 | 99.61% | Cx43 HC-IN-1 (Compound D4) is a selective and orally active inhibitor of connexin hemichannels (Cx43 HC). Cx43 HC-IN-1 effectively inhibits the hemichannel activity mediated by Cx43/Cx45 in denervated skeletal muscle fibers, significantly increasing the reinnervation rate of muscle fibers by neurons. Cx43 HC-IN-1 reduces neuroinflammation and neuronal overexcitation by inhibiting hemichannels in glial cells in the brain, and alleviates epilepsy in mice. Cx43 HC-IN-1 can be used for research on epilepsy and muscle diseases. | ||||||||||||||||||||
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- [1]. Cisterna BA, et al. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 2020 Feb 26;11(1):1073. [Content Brief]
- [2]. Guo A, et al. Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2213162119. [Content Brief]
Keywords
