943133-81-1
943133-81-1
Chemical Structure
Danegaptide Hydrochloride
Synonym(s): GAP-134 Hydrochloride; ZP 1609 Hydrochloride
- CAS No.: 943133-81-1
- Formula:C14H18ClN3O4
- Molecular Weight:327.76
IUPAC Name: (2S,4R)-4-benzamido-1-glycylpyrrolidine-2-carboxylic acid hydrochloride
InChIKey: AHXPMNACLWKFRQ-DHXVBOOMSA-N
SMILES: O=C(N[C@H]1CN(C(CN)=O)[C@H](C(O)=O)C1)C2=CC=CC=C2.[H]Cl
Biological Activity: Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect[1][2].
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Danegaptide Hydrochloride | 99.41% | Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect. | ||||||||||||||||||||
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Danegaptide Hydrochloride (Standard) | ≥98% | Danegaptide Hydrochloride (Standard) is the analytical standard of Danegaptide Hydrochloride (HY-10913A). This product is intended for research and analytical applications. Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect. | ||||||||||||||||||||
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References
- [1]. John A Butera, et al. Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation. J Med Chem. 2009 Feb 26;52(4):908-11. [Content Brief]
- [2]. Elke De Vuyst, et al. Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol. 2011 Jun;163(3):469-83. [Content Brief]
