1. Cytoskeleton
  2. Gap Junction Protein
  3. Gap19 TFA

Gap19 TFA 

Cat. No.: HY-P1136A
Handling Instructions

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial.

For research use only. We do not sell to patients.

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Gap19 TFA Chemical Structure

Gap19 TFA Chemical Structure

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Description

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial[1][2].

IC50 & Target

Cx43 Hemichannel[1]

In Vitro

Gap19 TFA (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 TFA (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 TFA (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 TFA (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].

In Vivo

Gap19 TFA (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2].

Animal Model: C57/BL6 mice[2]
Dosage: 25 mg/kg
Administration: IV; 10 min before ligation
Result: Significantly reduced the infarct size by approximately one-fifth.
Molecular Weight

1275.46

Formula

C₅₇H₉₇F₃N₁₄O₁₅

Sequence

{Lys}{Gln}{Ile}{Glu}{Ile}{Lys}{Lys}{Phe}{Lys}

Sequence Shortening

KQIEIKKFK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Gap19Gap 19Gap-19Gap Junction ProteinCx43connexinhemichannelC-terminusCTcytoplasmicloopCLGJchannelsCx40/pannexin-1myocardialInhibitorinhibitorinhibit

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Gap19 TFA
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HY-P1136A
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