2. Cytoskeleton
  3. Gap Junction Protein
  4. Gap19

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Gap19 TFA) usually boasts enhanced water solubility and stability.

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Gap19 Chemical Structure

Gap19 Chemical Structure

CAS No. : 1507930-57-5

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Gap19 Related Antibodies

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Description

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial[1][2].

IC50 & Target

Cx43 Hemichannel[1]
In Vitro

Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake[1].
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells[2].
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes[2].
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gap19 Related Antibodies
In Vivo

Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57/BL6 mice[2]
Dosage: 25 mg/kg
Administration: IV; 10 min before ligation
Result: Significantly reduced the infarct size by approximately one-fifth.
Molecular Weight

1161.44

Formula

C55H96N14O13
CAS No.
Sequence Shortening

KQIEIKKFK
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Gap19 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gap191507930-57-5Gap 19Gap-19Gap Junction ProteinCx43connexinhemichannelC-terminusCTcytoplasmicloopCLGJchannelsCx40/pannexin-1myocardialInhibitorinhibitorinhibit

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