1. Anti-infection
  2. CMV
  3. Brivudine

Brivudine (Synonyms: Bromovinyldeoxyuridine; BVDU)

Cat. No.: HY-13578 Purity: 98.87%
Handling Instructions

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

For research use only. We do not sell to patients.

Brivudine Chemical Structure

Brivudine Chemical Structure

CAS No. : 69304-47-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
25 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 70 In-stock
Estimated Time of Arrival: December 31
100 mg USD 90 In-stock
Estimated Time of Arrival: December 31
200 mg USD 140 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Description

Brivudine is a thymidine analogue with antiviral activity, indicated for the early treatment of acute herpes zoster.

In Vitro

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases, thus inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus compared with reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].

In Vivo

At a dose of 125 mg once daily, brivudine has proved to be superior to aciclovir with respect to reducing the period of new blister production, and has shortened the duration of post-herpetic neuralgia[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 330 mg/mL (990.57 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0017 mL 15.0087 mL 30.0174 mL
5 mM 0.6003 mL 3.0017 mL 6.0035 mL
10 mM 0.3002 mL 1.5009 mL 3.0017 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

333.14

Formula

C₁₁H₁₃BrN₂O₅

CAS No.

69304-47-8

SMILES

OC[[email protected]@H]1[[email protected]](C[[email protected]](N2C(NC(C(/C=C/Br)=C2)=O)=O)O1)O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Brivudine
Cat. No.:
HY-13578
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Brivudine

Cat. No.: HY-13578