Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities

  • Bioorg Med Chem Lett. 1999 Mar 22;9(6):827-30. doi: 10.1016/s0960-894x(99)00090-6.
K Kitano  1 ,  H Machida ,  S Miura ,  H Ohrui
Affiliations
  • 1. Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan.
PMID: 10206544 DOI: 10.1016/s0960-894x(99)00090-6
Abstract

Two novel 4'-C-methylnucleosides, 4'-methylBVDU 9 and 4'-methylBVaraU 10, were synthesized. The former was derived from 3',5'-di-O-acetyl-2'-deoxy-4'-C-methyluridine 12, and the latter was produced via glycosylation between 4-C-methyl-D-ribose derivative 11 and a silylated bromovinyl uracil. 4'-MethylBVDU 9 exhibited particularly potent anti-varicella-zoster virus (VZV) activity in vitro.