Valganciclovir hydrochloride
Based on 1 Customer Validation
Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 175865-59-5
- Formula: C14H23ClN6O5
- Molecular Weight:390.82
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Valganciclovir (500 μM, 5-7 days) inhibits the growth of human adenoviruses (Ads) in A549 cells[1]. Valganciclovir (0.003-10 mM, 10 min) with ganciclovir (HY-13637) inhibits the uptake of glycylsarcosine in Caco-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:500 μM
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Incubation Time:5 days, 7days
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Result:Showed EC50 values ranged from 120.5 μM (Ad4) to 244.4 μM (Ad6). Showed IC50 values was calculated to be 11.74 mM at 7 days post-infection.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Immunosuppressed hamsters[1]
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Dosage:200 mg/kg
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Administration:Oral gavage (p.o.)
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Result:Resulted in significantly smaller magnitude of weight loss for all groups.
Reduced the liver pathology.
Chemical Information
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CAS No. 175865-59-5
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Appearance Solid
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Molecular Weight 390.82
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Formula C14H23ClN6O5
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Color White to off-white
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SMILES
N[C@@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (127.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (127.94 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.40 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (255.87 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Toth K, et al. Valganciclovir inhibits human adenovirus replication and pathology in permissive immunosuppressed female and male Syrian hamsters [J]. Viruses, 2015, 7(3): 1409-1428. [Content Brief]
[2]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2 [J]. Journal of pharmaceutical sciences, 2000, 89(6): 781-789. [Content Brief]
[3]. Cvetkovic R S, et al. Valganciclovir: a review of its use in the management of CMV infection and disease in immunocompromised patients [J]. Drugs, 2005, 65: 859-878. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.5587 mL | 12.7936 mL | 25.5872 mL | 63.9681 mL |
| 5 mM | 0.5117 mL | 2.5587 mL | 5.1174 mL | 12.7936 mL | |
| 10 mM | 0.2559 mL | 1.2794 mL | 2.5587 mL | 6.3968 mL | |
| 15 mM | 0.1706 mL | 0.8529 mL | 1.7058 mL | 4.2645 mL | |
| 20 mM | 0.1279 mL | 0.6397 mL | 1.2794 mL | 3.1984 mL | |
| 25 mM | 0.1023 mL | 0.5117 mL | 1.0235 mL | 2.5587 mL | |
| 30 mM | 0.0853 mL | 0.4265 mL | 0.8529 mL | 2.1323 mL | |
| 40 mM | 0.0640 mL | 0.3198 mL | 0.6397 mL | 1.5992 mL | |
| 50 mM | 0.0512 mL | 0.2559 mL | 0.5117 mL | 1.2794 mL | |
| 60 mM | 0.0426 mL | 0.2132 mL | 0.4265 mL | 1.0661 mL | |
| 80 mM | 0.0320 mL | 0.1599 mL | 0.3198 mL | 0.7996 mL | |
| 100 mM | 0.0256 mL | 0.1279 mL | 0.2559 mL | 0.6397 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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