1. Anti-infection
  2. CMV
  3. Valganciclovir

Valganciclovir 

Cat. No.: HY-A0032
Handling Instructions

Valganciclovir, the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections.

For research use only. We do not sell to patients.

Valganciclovir Chemical Structure

Valganciclovir Chemical Structure

CAS No. : 175865-60-8

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Description

Valganciclovir, the L-valyl ester of ganciclovir, is actually a prodrug for ganciclovir. Valganciclovir is an antiviral medication used to treat cytomegalovirus infections. IC50 Value: Target: CMV in vitro: In cell culture model systems using Caco-2 cells for PEPT1 and SKPT cells for PEPT2, valganciclovir inhibited glycylsarcosine transport mediated by PEPT1 and PEPT2 with K(i) values (inhibition constant) of 1.68+/-0.30 and 0.043+/- 0.005 mM, respectively. The inhibition by valganciclovir was competitive in both cases [1]. in vivo: 37 patients were enrolled; 19 patients received treatment with VGV and 18 patients received treatment with GCV. The VGV was not inferior in efficacy to GCV as pre-emptive therapy, with rates of viral clearance at 28 days of 89.5% and 83%, respectively (P-value for non-inferiority = 0.030). Toxicities were similar between the 2 arms. No patients developed CMV disease [2]. Patients being treated with an alemtuzumab-containing regimen received prophylaxis with either valaciclovir 500 mg orally daily orvalganciclovir 450 mg orally twice daily. None of the 20 patients randomized to valganciclovir experienced CMV reactivation (P = .004) [3].

Clinical Trial
Molecular Weight

354.36

Formula

C₁₄H₂₂N₆O₅

CAS No.

175865-60-8

SMILES

N[[email protected]@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Valganciclovir
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HY-A0032
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