Valganciclovir

Cat. No.: HY-A0032: Data Sheet Handling Instructions
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Valganciclovir is an orally active antiviral agent. Valganciclovir can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir can be used for the research of Cytomegalovirus.

For research use only. We do not sell to patients.

Valganciclovir Chemical Structure

CAS No. : 175865-60-8

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5 mg	Get quote 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks	Estimated Time of Arrival: December 31
10 mg	Get quote 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks	Estimated Time of Arrival: December 31
25 mg	Get quote 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks	Estimated Time of Arrival: December 31
100 mg	Get quote 3 - 5 weeks 2 - 4 weeks 4 - 6 weeks 2 - 4 weeks	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of Valganciclovir:

Valganciclovir hydrochloride In-stock
Valganciclovir-d₅ TFA Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Valganciclovir (500 μM, 5-7 days) inhibits the growth of human adenoviruses (Ads) in A549 cells^[1].
Valganciclovir (0.003-10 mM, 10 min) with ganciclovir (HY-13637) inhibits the uptake of glycylsarcosine in Caco-2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	A549 cells
Concentration:	500 μM
Incubation Time:	5 days, 7days
Result:	Showed EC₅₀ values ranged from 120.5 μM (Ad4) to 244.4 μM (Ad6). Showed IC₅₀ values was calculated to be 11.74 mM at 7 days post-infection.

In Vivo

Valganciclovir (200 mg/kg, Oral gavage, twice daily for16 days) protects immunosuppressed hamsters challenged intravenously with adenovirus type 5 (Ad5)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Immunosuppressed hamsters^[1]
Dosage:	200 mg/kg
Administration:	Oral gavage (p.o.)
Result:	Resulted in significantly smaller magnitude of weight loss for all groups. Reduced the liver pathology.

Clinical Trial

Molecular Weight

354.36

Formula

C₁₄H₂₂N₆O₅

CAS No.

175865-60-8

SMILES

N[C@@H](C(C)C)C(OCC(OCN1C=NC2=C1N=C(N)NC2=O)CO)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Toth K, et al. Valganciclovir inhibits human adenovirus replication and pathology in permissive immunosuppressed female and male Syrian hamsters [J]. Viruses, 2015, 7(3): 1409-1428. [Content Brief]

[2]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9. [Content Brief]

[3]. Cvetkovic R S, et al. Valganciclovir: a review of its use in the management of CMV infection and disease in immunocompromised patients [J]. Drugs, 2005, 65: 859-878. [Content Brief]

Valganciclovir Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valganciclovir175865-60-8CMVCytomegalovirusA549 cellsCaco-2 cellsImmunosuppressed hamstersInhibitorinhibitorinhibit

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