1. Anti-infection
    Apoptosis
    Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. CMV
    Apoptosis
    DNA/RNA Synthesis
    Orthopoxvirus
    Endogenous Metabolite
  3. Cidofovir

Cidofovir  (Synonyms: GS 0504; HPMPC; (S)-HPMPC)

Cat. No.: HY-17438 Purity: 99.15%
COA Handling Instructions

Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir also has anti-orthopoxvirus and anti-variola activities.

For research use only. We do not sell to patients.

Cidofovir Chemical Structure

Cidofovir Chemical Structure

CAS No. : 113852-37-2

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 106 In-stock
Estimated Time of Arrival: December 31
100 mg USD 172 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cidofovir:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cidofovir

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir also has anti-orthopoxvirus and anti-variola activities[4].

In Vitro

Cidofovir (5-100 μM, 72 hours) has antiviral activity against feline herpesvirus type-1 (FHV-1) with an IC50 of 11 μM, and can reduce Crandell-Reese feline kidney cell counts in a dose-dependent manner[1].
Cidofovir (10-1000 μM, 24-120 hours) can reduce cancer cell viability and induces apoptosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: Crandell-Reese feline kidney(CRFK) cells
Concentration: 10-100 μM
Incubation Time: 72 hours
Result: Reduced CRFK cells by 9.1%.

Cell Viability Assay[3]

Cell Line: Caco-2, FTC-133, HeLa, Hep-G2, MDA-MB-231, NCI-H1975 and PC-3 cells
Concentration: 10-1000 μM
Incubation Time: 24, 48, 72, 96, 120 hours
Result: Resulted in a gradual decrease in tumor cell viability with time and concentration increasing and inhibited the number of FTC-133 cell clones by about 55% at 100 μM comparing to the untreated group.

Apoptosis Analysis[3]

Cell Line: FTC-133 cells
Concentration: 100 μM
Incubation Time: 96 hours
Result: Showed a significant increase in the expression of pro-apoptotic proteins, such as cytochrome c, phospho-p53 (S15) and caspase-3 by 130%, 49%, and 46%, respectively while the anti-apoptotic protein Bcl-x decreased significantly by 57% comparing to the untreated cells.
In Vivo

Cidofovir (subcutaneous injection, 100 mg/kg, 3-6 days interval, 21 days) is highly protective against death from cowpox virus (CPV) infection at high doses in female weanling BALB/c mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female weanling BALB/c mice infected with cowpox virus (CPV)[2]
Dosage: 100 mg/kg
Administration: Subcutaneous injection; 3-6 days interval; 21 days
Result: Prevented 80-100% of mouse deaths when administered on the first 4-3 days before infection.
Protected 35-50% of mice when administered on the fourth day after infection, and 10-20% when administered on the sixth day.
Clinical Trial
Molecular Weight

279.19

Formula

C8H14N3O6P

CAS No.
SMILES

OC[[email protected]@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 3.33 mg/mL (11.93 mM; Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5818 mL 17.9090 mL 35.8179 mL
5 mM 0.7164 mL 3.5818 mL 7.1636 mL
10 mM 0.3582 mL 1.7909 mL 3.5818 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 4.55 mg/mL (16.30 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.15%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Cidofovir
Cat. No.:
HY-17438
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