2. Anti-infection Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
  4. Cidofovir sodium

Cidofovir sodium  (Synonyms: GS 0504 sodium; HPMPC sodium; (S)-HPMPC sodium)

Cat. No.: HY-167911
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Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities.

For research use only. We do not sell to patients.

CAS No. : 127749-27-3

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Cidofovir sodium Related Antibodies

Top Publications Citing Use of Products

    Cidofovir sodium purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2025 Oct 16;18(10):1560.  [Abstract]

    The cytotoxicity of three reference compounds (GCV, CDV (Cidofovir), and BCV) on COS-7 cells was tested.

    Cidofovir sodium purchased from MedChemExpress. Usage Cited in: Virol Sin. 2025 Mar 25:S1995-820X(25)00031-8.  [Abstract]

    HEK293T cells were transfected with pHBoV1-HiBiTNS1 in the presence of Cidofovir (200 ​μM), favipiravir (50 ​μM), ivermectin (10 ​μM), nevirapine (50 ​μM), remdesivir (10 ​μM), ribavirin (50 ​μM), sofosbuvir (50 ​μM), or zidovudin (50 ​μM). At 72 ​h post-transfection, the Nano-Glo luciferase assay was performed.

    Cidofovir sodium purchased from MedChemExpress. Usage Cited in: J Virol. 2025 Jan 23:e0153924.  [Abstract]

    Antiviral activity of cidofovir against HBoV1. MA104 cells were treated with 50, 100, 200, 400 µM cidofovir for 6 h and then infected with HBoV1 for 12 h, and the intracellular viral DNA copies were detected at 96 h.p.i.

    Cidofovir sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2024 Dec;103(12):104238.  [Abstract]

    DEFs infected DPV at MOI=1, then treated with Cidofovir (10 nmol) for 1 h, 2 h, 3 h, 4 h, 6 h, 8 h, 10 h, 12 h, 14 h and 16 h, qRT-PCR detected DPV copy numbers in the supernatant.

    Cidofovir sodium purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2023 Dec;12(1):2208682.  [Abstract]

    Cytotoxicity of Cidofovir and its Inhibition efficiency on WIBP-MPXV-001

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    Description

    Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities[4].

    IC50 & Target

    DNA Polymerase

     

    Molecular Weight

    323.15

    Formula

    C8H12N3Na2O6P
    CAS No.
    SMILES

    OC[C@@H](OCP(O[Na])(O[Na])=O)CN1C=CC(N)=NC1=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Cidofovir sodium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cidofovir127749-27-3GS 0504HPMPC(S)-HPMPCGS0504GS-0504CMVApoptosisDNA/RNA SynthesisOrthopoxvirusEndogenous MetaboliteCytomegalovirusantiviralcytomegalovirusretinitisherpescancerInhibitorinhibitorinhibit

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