127749-27-3
Chemical Structure
Cidofovir sodium
Synonym(s): GS 0504 sodium; HPMPC sodium; (S)-HPMPC sodium
- CAS No.: 127749-27-3
- Formula:C8H12N3Na2O6P
- Molecular Weight:323.15
InChIKey: HKIAHFPOQYDOHP-ILKKLZGPSA-L
SMILES: OC[C@@H](OCP(O[Na])(O[Na])=O)CN1C=CC(N)=NC1=O
Biological Activity: Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities[4].
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Cidofovir sodium | Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities. | |||||||||||||||||||||
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Cidofovir-13C,15N2 disodium | Cidofovir-13C,15N2 disodium (GS 0504-13C,15N2 disodium) is the 13C- and 15N-labeled Cidofovir disodium (HY-167911). Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities. | |||||||||||||||||||||
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- [1]. David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65(4):399-403. [Content Brief]
- [3]. Simona Catalani, et al. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55. [Content Brief]
- [4]. Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57(1-2):13-23. [Content Brief]
