1. Anti-infection
  2. CMV
    HSV
  3. Brincidofovir

Brincidofovir (Synonyms: CMX001; HDP-CDV)

Cat. No.: HY-14532 Purity: >98.0%
Handling Instructions

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections.

For research use only. We do not sell to patients.

Brincidofovir Chemical Structure

Brincidofovir Chemical Structure

CAS No. : 444805-28-1

Size Stock
10 mM * 1 mL in DMSO Get quote
2 mg USD 480 Get quote
5 mg USD 720 Get quote
10 mg USD 1140 Get quote
25 mg USD 2160 Get quote
50 mg USD 4320 Get quote

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Description

Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections[1][2].

IC50 & Target

EC50: 5.5 nM (anti-CMV, in PDA at 7 dpi)

In Vivo

Brincidofovir (BCV) (20 mg/kg; p.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24) extends survival in immune-deficient BALB/c nu/nu mice following lethal challenge with IHD-J-Luc VACV[3].

Animal Model: BALB/c nu/nu mice (infected with IHD-J-Luc VACV)[3]
Dosage: 20 mg/kg
Administration: P.o.; on days 1, 3, 5, 7, 10, 14, 17, 21, and 24
Result: On days 1, 3, and 5 maintained their weights initially but started to lose weight beginning on day 9 and succumbed between days 24 and 29 postchallenge.
Clinical Trial
Molecular Weight

561.69

Formula

C₂₇H₅₂N₃O₇P

CAS No.

444805-28-1

SMILES

NC1=NC(N(C[[email protected]@H](CO)OCP(O)(OCCCOCCCCCCCCCCCCCCCC)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (1.78 mM; adjust pH to 8 with NaOH and heat to 50°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7803 mL 8.9017 mL 17.8034 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BrincidofovirCMX001 HDP-CDVCMX 001CMX-001CMVHSVCytomegalovirusHerpes simplex viruslipid-conjugatedprodrugantiviralDNAvirusesinfectionInhibitorinhibitorinhibit

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Brincidofovir
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